Red light therapy in conjunction with the time tested science of Acupuncture
Light Therapy for Fertility and Conception
Infertility and subfertility are on the rise, in both women and men, all across the world.
Being infertile is the inability, as a couple, to get pregnant after 6 – 12 months of trying. Subfertility refers to having a reduced chance of becoming pregnant, relative to other couples.
It is estimated that 12-15% of couples want, but are unable, to conceive. Due to this, fertility treatments such as IVF, IUI, hormonal or drug approaches, surgical procedures, and more, are rapidly increasing in popularity.
Light therapy (sometimes known as photobiomodulation, LLLT, red light therapy, cold laser, etc.) shows promise for improving the health of a lot of different body parts, and has been studied for both female fertility and male fertility. Is light therapy a valid fertility treatment? In this article we will discuss why light might be all you need…
Introduction
Infertility is a worldwide crisis for both males and females, with fertility rates rapidly decreasing, in some countries more so than others. 10% of all babies currently born in Denmark were conceived through the help of IVF and similar reproductive technologies. 1 in 6 couples in Japan are infertile, with the Japanese government recently intervening to pay for couple’s IVF costs in order to stop the unfolding population crisis. The government in Hungary, desperate to increase low birth rates, has made it so women that have 4 children or more will be exempt for life from having to pay income tax. The births per woman in some European countries is as low as 1.2, and even as low as 0.8 in Singapore.
More and more couples are turning to IVF and similar treatments as time goes on. Almost all European countries, Japan, USA, Canada, Israel, Australia and others are progressively relying on assisted fertility treatments to achieve pregnancies.
Birth rates have been declining worldwide, since at least the 1950s and in some regions before that. It’s not just human infertility that is on the rise, various species of animals are also having problems, such as farm and domestic animals. Part of this decline in birth rates is due to socioeconomic factors – couples are choosing to try for children later, when natural fertility has already declined. Another part of the decline is environmental, dietary and hormonal factors. For example sperm counts in the average male have decreased by 50% in the last 40 years. So men today are only producing half as many sperm cells as their fathers and grandfathers did back in their youth. Female reproductive disorders such as polycystic ovarian syndrome (PCOS) now affect up to 10% of women. Endometriosis (a condition where uterine tissue grows in other areas of the reproductive system) also affects another 1 in 10 women, so almost 200 million women worldwide.
Light therapy is a novel treatment idea for infertility, and although it falls under the same ‘ART’ (assisted reproductive technology) classification as IVF, it is a much cheaper, non-invasive, and easier to access treatment. Light therapy is very well established for the treatment of eye health issues, pain problems, would healing, etc., and is being vigorously studied across the world for a wide range of conditions and body parts. Most of the current light therapy for fertility research is coming out of 2 countries – Japan and Denmark – especially for research on female fertility.
Is there a role for light therapy products to address fertility issues?
Thyroid problems and PCOS are among the leading causes of infertility, both being severely underdiagnosed (Read more about thyroid health and light therapy here). Endometriosis, fibroids and other unwanted internal growths account for another large percentage of infertility cases. When a woman is infertile, 30%+ of the time there will be some degree of endometriosis. Other common infertility causes are; fallopian tube blockages, internal scarring from surgery (including C-sections), and other ovulation problems besides pcos (anovulation, irregular, etc.). In many cases the cause of infertility is just unexplained – it’s not known why. In some cases conception and egg implantation occur, but at a later point in early pregnancy there is a miscarriage.
With the rapid rise of fertility problems, there has been a commensurate rise in infertility treatments and research. Japan as a country has one of the worst fertility crises in the world, with one of the highest rates of IVF use. They are also pioneers in studying the effects of light therapy on improving female fertility….
Light therapy and female fertility
Light therapy uses either red light, near infrared light, or a combination of both. The ideal type of light for a specific purpose varies based on the part of the body.
When looking at female fertility specifically, the primary targets are the uterus, ovaries, fallopian tubes and general hormonal systems (thyroid, brain, etc.). All of these tissues are inside the body (unlike male reproductive parts), and so the type of light with the best penetration is necessary, as only a small percentage of the light hitting the skin will penetrate down into tissues like ovaries. Even with the wavelength that gives the optimal penetration, the amount that penetrates is still very small, and so a very high intensity of light is required as well.
Near infrared light at wavelengths between 720nm and 840nm have the best penetration into biological tissue. This range of light is known as the ‘Near Infrared Window (into biological tissue)” because of the unique properties of passing deep into the body. Researchers looking at improving female infertility with light have overwhelmingly selected the 830nm near infrared wavelength for study(1-6). This 830nm wavelength not only penetrates well, but also has potent effects on our cells, improving their function.
Light on the neck
Some of the early research out of Japan was based on ‘The Proximal Priority Theory’. The basic idea is that the brain is the master organ of the body and all other organs and hormonal systems are downstream from the brain. Whether or not this idea is correct, there is some truth to it. Researchers used 830nm near infrared light on the neck of infertile Japanese women(1), hoping that the direct and indirect (via the blood) effects on the brain would ultimately lead to better hormonal and metabolic situations across the entire body(3), especially the reproductive system. The results were great, with a high percentage of women previously deemed ‘severely infertile’ not only getting pregnant, but also achieving live births(1,2,4) – welcoming their baby into the world.
Following on from the studies using light on the neck, researchers were interested in whether or not light therapy might improve the success rates of natural pregnancies and IVF.
In vitro fertilization is known as a last resort when traditional methods of conception have failed. The cost per cycle can be very high, even unfeasible for many couples, with others taking out loans as a gamble to fund it. The success rates of IVF can be very low, especially in women aged 35 years or more. Given the high cost and low success rate, improving the chances of an IVF cycle is critical to achieve the goal of pregnancy. Eliminating the need for IVF and getting pregnant naturally after failed cycles is even more appealing.
Implantation rates of the fertilized egg (critical for both IVF and regular pregnancy) are thought to be related to mitochondrial function(8). Lower performing mitochondria hinder the functioning of the egg cell. The mitochondria found in egg cells are inherited from the mother, and can have DNA mutations in certain women, especially as age advances. Red and near infrared light therapy work directly on the mitochondria, improving the function and reducing issues like DNA mutations. This explains why a study from Denmark showed that two-thirds of women who previously had failed IVF cycles achieved a successful pregnancy (even natural pregnancies) with light therapy. There was even a case of a 50 year old woman getting pregnant.
Light on the abdomen
The protocol used in this study from Denmark(7) involved 3 near infrared light therapy sessions per week, with the light being directly applied to the abdomen, at quite a large dose. If the woman did not conceive during the current menstrual cycle, treatments continued into the next. Out of a sample of 400 previously infertile women, a whopping 260 of them were able to conceive following near infrared light treatments. Declining egg quality is not an irreversible process, it would seem. This research raises questions over the ART process of removing a woman’s egg nucleus and inserting it into the egg cells of a donor (known as mitochondrial transfer, or 3-person/parent babies) – is it really necessary when a woman’s own egg cells can be potentially restored with a non-invasive therapy.
Human egg cells – Mitochondria are the key part of egg cells that determine fertility and viability. Red and near infrared light (
Using light therapy directly on the abdomen (to target the ovaries, uterus, fallopian tubes, egg cells, etc.) is thought to work in 2 ways. Firstly is optimizes the environment of the reproductive system, ensuring egg cells are released during ovulation, can travel down the fallopian tubes, and can implant into a healthy uterus wall with good blood flow, a healthy placenta can form, etc.(23). The other mechanism involves improving the health of the egg cell directly. Oocyte cells, or egg cells, require huge amounts of energy compared to other cells for the processes related to cell division and growth. This energy is provided by mitochondria – the part of a cell affected by light therapy. Declining mitochondrial function can be seen as the key cellular cause of infertility (8). This may be the key explanation for most cases of ‘unexplained’ fertility and why fertility declines with advancing age – the egg cells just can’t make enough energy. Evidence that they require and use so much more energy is found by the fact that there are 200 times more mitochondria in egg cells when compared to other regular cells. That’s 200 times more potential for effects and benefits from light therapy relative to other cells in the body. Of every cell in the entire human body, male or female, the egg cell may be the type that receives the most drastic enhancements from red and near infrared light therapy. The only problem is getting the light to penetrate down to the ovaries (more on that below).
Both of these light therapies or ‘photobiomodulation’ effects together create a healthy and youthful environment, suitable to support a growing embryo.
Almost every cell in our body has mitochondria – the target of red light therapy – including Sertoli Cells. These are the sperm producing cells of the testes – the place where sperm is manufactured. Proper functioning of these cells is essential for all aspects of male fertility, including sperm counts.
Studies point to light therapy improving the quantity of Sertoli Cells in the male testicles, their performance (and so the amount of sperm cells/count that they produce), and also decreasing the production of abnormal sperm cells. Overall sperm counts have been shown to improve by 2-5 times in males with previously low counts. In one study from Denmark(7), sperms counts increased from 2 million per ml to over 40 million per ml with only one treatment to the testicles.
Higher sperm counts, faster sperm motility, and less abnormal sperm are some of the key reasons why light therapy is an essential part of improving any male fertility issue.
The mechanism – what red/infrared light does
To properly understand why red/IR light helps with both male and female fertility, we need to know how it works on a cellular level.
Mechanism
The effects of red and near infrared light therapy are thought to come from the interaction with our cells’ mitochondria. This ‘photobiomodulation’ happens when the appropriate wavelengths of light, between 600nm and 850nm, are absorbed by a mitochondrion, and ultimately lead to better energy production and less inflammation in the cell.
One of the key targets of light therapy is an enzyme called Cytochrome C Oxidase – part of the electron transport chain process of energy metabolism. It is understood that there are several other parts of the mitochondria that are also affected. These mitochondria are extremely prevalent in egg and sperm cells.
Shortly after a light therapy session, it is possible to see the release of a molecule called Nitric Oxide from cells. This NO molecule actively inhibits respiration, blocking energy production and oxygen consumption. So, removing it from the cell restores the normal healthy function. Red and near infrared light are thought to dissociate this stress molecule from the Cytochrome C Oxidase enzyme, restoring the healthy level of oxygen utilisation and energy production.
Red light therapy improves our natural process of making cellular energy
Light therapy also has an effect on the water inside our cells, structuring it with more space between each molecule. This changes the chemical and physical properties of the cell, meaning that nutrients and resources can enter more readily, toxins can be expelled with less resistance, enzymes and proteins work more efficiently. This effect on cellular water applies not just directly inside the cells, but also outside it, in the extracellular space and tissues like blood.
This is just a quick summary of 2 potential mechanisms of action. There are possibly more, not fully understood, beneficial effects that happen on a cellular level to explain the results from light therapy.
All of life interacts with light – plants need light for food, humans need ultraviolet light for vitamin D, and as all the studies show, red and near infrared light are essential to humans and various animals for a healthy metabolism and even reproduction.
The effects of light therapy are not just seen in the target area of the session, but also systemically. For example a session of light therapy on your hand can provide benefits to the heart. A session of light therapy on the neck can provide benefits to the brain, which can in turn improve hormone production/status and lead to dramatic whole body health improvements. Light therapy is essential for removing cellular stress and enabling your cells to function normally again and the cells of the reproductive system are no different.
Summary
- Light therapy has been studied for human/animal fertility for decades
- Near Infrared light studied to improve fertility status in females
- Improves energy production in egg cells – critical for pregnancy
- Red Light therapy is shown to improve energy production in Sertoli cells and sperm cells, which leads to increased sperm counts and quality
- All aspects of reproduction (male and female) require large amounts of cellular energy
- Light therapy helps cells to meet the energy demands
- LEDs and lasers are the only devices that are well studied.
- Red wavelengths between 620nm and 670nm are ideal for males.
- Near Infrared light around the 830nm range seems best for female fertility.